Product Pipeline

Pipeline Overview

Product Mechanism Ownership Indication Preclinical Clinical Stage Phase 1/2
Tuspetinib* Myeloid Kinase Aptose WW AML
complete
AML Preclinical Phase complete
in progress
Clinical Stage Phase 1/2 Phase in progress
Luxeptinib** Lymphoid Kinase Aptose: WW
Crystal Genomics: Korea
CLL & NHL
complete
CLL & NHL Preclinical Phase complete
in progress
Clinical Stage Phase 1/2 Phase in progress
Luxeptinib** Myeloid Kinase Aptose: WW
Crystal Genomics: Korea
AML & MDS
complete
AML & MDS Preclinical Phase complete
in progress
Clinical Stage Phase 1/2 Phase in progress
APTO-253 MYC, KLF4 Aptose: WW AML & MDS
complete
AML & MDS Preclinical Phase complete
in progress
Clinical Stage Phase 1/2 Phase in progress
APL-581 BRD4/JAK Aptose and Ohm Hematologic Cancers
in progress
Hematologic Cancers Preclinical Phase in progress
not started
Clinical Stage Phase 1/2 Phase not started


*formerly HM43239

**formerly CG-806

Luxeptinib for B-cell Tumors

Luxeptinib for B-cell Tumors

Oral, Mutation-Agnostic, Dual Lymphoid / Myeloid Kinase Inhibitor (LKI/MKI)

Luxeptinib is being developed for the treatment of patients with certain B-cell malignancies, including chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), and certain non-Hodgkin’s lymphomas (NHL) who are resistant or intolerant to conventional treatments.

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Luxeptinib for Myeloid Tumors

Luxeptinib for Myeloid Tumors

Oral, Mutation-Agnostic, Dual Lymphoid / Myeloid Kinase Inhibitor (LKI/MKI)

Luxeptinib is also being developed for the treatment of patients with relapsed or refractory acute myeloid leukemia (AML), including the emerging populations resistant to approved targeted therapies.

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Tuspetinib (HM43239) for Myeloid Tumors

Tuspetinib (HM43239) for Myeloid Tumors

Oral, Potent Myeloid Kinase Inhibitor (MKI)

Tuspetinib (HM43239) is being developed for the treatment of patients with relapsed or refractory acute myeloid leukemia (AML).

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Posters & Presentations

Posters & Presentations

Our online library includes numerous publications, including presentations, posters, and other media that provide additional information on preclinical and clinical studies of our drug candidates.

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