Aptose Biosciences Inc.

Precision Oncology for Therapies of Tomorrow

Aptose Biosciences is a science-driven clinical-stage biotechnology company committed to precision medicines addressing the unmet clinical needs in oncology, with an initial focus on hematology. The Company's small molecule cancer therapeutics pipeline includes products designed to provide single agent efficacy and to enhance the efficacy of other anti-cancer therapies and regimens without overlapping toxicities.

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Broad Applicability Across the Hematology Spectrum

Our drug candidates have been designed to provide safe single agent efficacy in multiple adjacent indications, as well as enhance the efficacy of other anti-cancer therapies and regimens without overlapping toxicities.

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Tuspetinib (formerly HM43239): Myeloid Kinase Inhibitor (MKI) for AML

Tuspetinib is a potent oral inhibitor of key kinases operative in myeloid malignancies, including SYK, FLT3, JAK, c-KIT(mut), and others.

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Luxeptinib: Lymphoid Kinome Inhibitor (LKI) for B-NHL

Luxeptinib is a potent non-covalent inhibitor of wildtype and mutant forms of BTK, as well as multiple oncogenic signaling pathways operative in CLL and other B-cell malignancies.

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Luxeptinib: Myeloid Kinome Inhibitor (MKI) for AML/MDS

Luxeptinib potently inhibits wildtype and all mutant forms of FLT3 which are an oncogenic drivers in AML and MDS, as well as other oncogenic rescue pathways operative in myeloid malignancies.

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Our Clinical Trials in Hematologic Malignancies

Currently, we have three ongoing clinical trials with our investigational drug candidates:

Tuspetinib: Phase 1/2

Tuspetinib is in a Phase 1/2 clinical trial for the treatment of patients with relapsed or refractory AML

Luxeptinib: Phase 1a/b

Luxeptinib is in a Phase 1a/b clinical trial for the treatment of patients with B-cell malignancies, including CLL and NHL, who have failed or are intolerant to the standard treatments available.