Quarterly report pursuant to Section 13 or 15(d)

Note 10 - Related party transactions (Details Textual)

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Note 10 - Related party transactions (Details Textual) - USD ($)
 9 Months Ended 23 Months Ended
Sep. 30, 2023
Sep. 06, 2023
Nov. 04, 2021
Sep. 30, 2023
Sep. 30, 2022
Sep. 30, 2023
Aug. 10, 2023
Dec. 31, 2022
Schedule of Equity Method Investments [Line Items]                
Accrued liabilities $ 9,129,000     $ 9,129,000   $ 9,129,000   $ 5,657,000
Accounts payable 2,811,000     2,811,000   2,811,000   6,326,000
HM43239 [Member]                
Schedule of Equity Method Investments [Line Items]                
License Fee, Total     $ 12,500,000          
Payments for License Fee     5,000,000          
Stock Issued During Period, Value, Licensing Fee     $ 7,500,000          
Supply Agreement [Member]                
Schedule of Equity Method Investments [Line Items]                
Expenses       3,100,000 $ 1,800,000 6,700,000    
Payment of supply costs           4,500,000    
Accrued liabilities $ 2,200,000     $ 2,200,000   $ 2,200,000   572,000
Accounts payable               $ 3,000,000
Hanmi Pharmaceuticals Co., Ltd. [Member]                
Schedule of Equity Method Investments [Line Items]                
Number of common shares held 884,152   215,703 884,152   884,152    
Future milestone payments     $ 407,500,000          
Proceeds of sale stock $ 3,000,000 $ 3,000,000            
Payment of supply costs       $ 4,500,000 $ 0      
Hanmi Pharmaceuticals Co., Ltd. [Member] | Common Shares [Member]                
Schedule of Equity Method Investments [Line Items]                
Number of shares sold   668,449            
Maximum [Member] | Hanmi Pharmaceuticals Co., Ltd. [Member]                
Schedule of Equity Method Investments [Line Items]                
Investment for ownership interest             $ 7,000,000  
Percentage of investment   19.99%         19.99%  
Maximum [Member] | Hanmi Pharmaceuticals Co., Ltd. [Member] | Second Tranche [Member]                
Schedule of Equity Method Investments [Line Items]                
Investment for ownership interest   $ 4,000,000