Annual report pursuant to Section 13 and 15(d)

Note 12 - Stock-based Compensation - Share-based Payment Expense (Details)

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Note 12 - Stock-based Compensation - Share-based Payment Expense (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Share-based payment expense $ 12,949 $ 21,438
Research and Development Expense [Member]    
Share-based payment expense 3,789 3,720
General and Administrative Expense [Member]    
Share-based payment expense $ 9,160 $ 17,718