Exhibit
99.1
|
NEWS
RELEASE |
Lorus
Therapeutics Announces Ohio State University Received a $2 Million
US
National Institutes of Health grant to Evaluate
Novel Nanoparticle
Delivery
Technology with Lorus’ Oncology Drugs
TORONTO, CANADA - March 24,
2009 - Lorus Therapeutics Inc. (TSX: LOR) (“Lorus” or the “Corporation”), a
biopharmaceutical company specializing in the research and development of
pharmaceutical products and technologies for the management of cancer, today
announced that researchers at the Ohio State University (OSU) have received a
grant of approximately US $2 million to explore the potential for applying OSU’s
proprietary tumor-targeted nanoparticle drug delivery technology with
ribonucleotide reductase (RNR) targeted RNA-based drugs.
LOR-1284,
an siRNA drug candidate targeting the R2 component of ribonucleotide reductase
(RNR), has been chosen by OSU as the lead compound for this study. Lorus agreed
to supply LOR-1284 along with other developmental compounds that target R1 and
R2, all of which have shown strong preclinical or clinical activity against a
variety of cancers. Although in published reports LOR-1284 has shown significant
in vivo anti-tumor
activity on its own, the novel nanotechnology approach in development by OSU has
the potential to enhance uptake of the drug in tissues and to provide a
selective affinity for specific tumors.
Research
to optimize delivery of siRNA in vivo is expected to be the
key to the future therapeutic promise of siRNA therapeutics to effectively
target specific genes associated with cancer.
Development
of nanomedicines has been a strong area of growth in innovative technologies at
OSU, and leverages expertise at the OSU College of Pharmacy, the Nanoscale
Science and Engineering Center (NSEC), and Comprehensive Cancer Center (CCC).
Dr. Robert Lee, Associate Professor of Pharmaceutics in the CCC and NSEC, is
providing overall direction of this experimental program in collaboration with
Dr. James Lee, Professor in the Department of Chemical and Biomolecular
Engineering and Director of NSEC, and Dr. Guido Marcucci, Professor of Medicine
and Human Genetics in the CCC.
“Coupling
novel lipid-based nanocarriers with tumor-specifc molecular targeting agents, is
a rational and promising approach for concentrating the activity of RNA-based
drugs, and combines two complementary technologies already in development at
OSU”, said Dr. Robert Lee. “OSU has ongoing research experience with a number of
siRNA and oligonucleotide drugs. This includes an ongoing program with Lorus’
LOR-2040 drug in Acute Myeloid Leukemia that is presently in an advanced Phase
II clinical study”.
“Lorus
is very pleased to provide our compounds targeting ribonucleotide reductase R1
and R2 and supporting information to explore a novel way of delivering these
drugs”, said Lorus’ CEO Dr. Aiping Young. “This research exploits the broad
spectrum of antitumor activity of these compounds to identify additional
development opportunities for specific tumors.
Lorus
is supplying the drugs under a Materials Transfer Agreement.
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About
Lorus
Lorus
is a biopharmaceutical company focused on the research and development of novel
therapeutics in cancer. Lorus’ goal is to capitalize on its research,
preclinical, clinical and regulatory expertise by developing new drug candidates
that can be used, either alone, or in combination with other drugs, to
successfully manage cancer. Through its own discovery efforts and an
acquisition and in-licensing program, Lorus is building a portfolio of promising
anticancer drugs. Lorus Therapeutics Inc. is listed on the Toronto
Stock Exchange under the symbol LOR.
Forward
Looking Statements
This
press release contains forward-looking statements within the meaning of Canadian
and U.S. securities laws. Such statements include, but are not limited to,
statements relating to: financings and corporate reorganizations, the
establishment of corporate alliances, the Company’s plans, objectives,
expectations and intentions and other statements including words such as
“continue”, “expect”, “intend”, “will”, “should”, “would”, “may”, and other
similar expressions. Such statements reflect our current views with respect to
future events and are subject to risks and uncertainties and are necessarily
based upon a number of estimates and assumptions that, while considered
reasonable by us are inherently subject to significant business, economic,
competitive, political and social uncertainties and contingencies. Many factors
could cause our actual results, performance or achievements to be materially
different from any future results, performance or achievements described in this
press release. Such expressed or implied forward looking statements could
include, among others: our ability to continue as a going concern, our ability
to repay or refinance the convertible debentures by October 2009, the actual
number of shares to be issued in the future as a result of warrant exercised;
use of proceeds of the Rights Offering; the inherent risks in early stage drug
development including demonstrating efficacy; development time/cost and the
regulatory approval process; the progress of our clinical trials; our ability to
find and enter into agreements with potential partners; our ability to attract
and retain key personnel; changing market conditions; and other risks detailed
from time-to-time in our ongoing quarterly filings, annual information forms,
annual reports and annual filings with Canadian securities regulators and the
United States Securities and Exchange Commission.
Should
one or more of these risks or uncertainties materialize, or should the
assumptions set out in the section entitled “Risk Factors” in our filings with
Canadian securities regulators and the United States Securities and Exchange
Commission underlying those forward-looking statements prove incorrect, actual
results may vary materially from those described herein. These forward-looking
statements are made as of the date of this press release and we do not intend,
and do not assume any obligation, to update these forward-looking statements,
except as required by law. We cannot assure you that such statements
will prove to be accurate as actual results and future events could differ
materially from those anticipated in such statements. Investors are cautioned
that forward-looking statements are not guarantees of future performance and
accordingly investors are cautioned not to put undue reliance on forward-looking
statements due to the inherent uncertainty therein.
Lorus
Therapeutics Inc.’s recent press releases are available through the Company’s
website at www.lorusthera.com. For Lorus' regulatory filings on SEDAR, please go
to www.Sedar.com. For SEDAR filings prior to July 10, 2007 you will
find these under the company profile for Global Summit Real Estate Inc. (Old
Lorus).
Enquiries:
For
further information, please contact:
Lorus
Therapeutics Inc.
Dr.
Saeid Babaei, 416-798-1200 ext. 490; ir@lorusthera.com
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