FORM 3
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  Wilson Donald R. Jr.
2. Date of Event Requiring Statement (Month/Day/Year)
08/03/2021
3. Issuer Name and Ticker or Trading Symbol
Aptose Biosciences Inc. [APTO]
(Last)
(First)
(Middle)
540 W. MADISON ST., SUITE 2500, 
4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

CHICAGO, IL 60661
6. Individual or Joint/Group Filing(Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)
2. Amount of Securities Beneficially Owned
(Instr. 4)
3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)
4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 4,162
I
Through DRW Commodities, LLC (1) (2)
Common Stock 8,891,076
I
Through DRW Investments, LLC (1) (2)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)
2. Date Exercisable and Expiration Date
(Month/Day/Year)
3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)
4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)
6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Wilson Donald R. Jr.
540 W. MADISON ST., SUITE 2500
CHICAGO, IL 60661
    X    
DRW Commodities, LLC
540 W. MADISON ST., SUITE 2500
CHICAGO, IL 60661
    X    
DRW Holdings, LLC
540 W. MADISON ST.
SUITE 2500
CHICAGO, IL 60661
    X    

Signatures

/s/ Donald R. Wilson, Jr. 08/05/2021
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) This Form 3 is being filed by the undersigned Donald R. Wilson Jr. ("Wilson"), as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the "Reporting Persons"). Wilson is the sole manager of each of DRW Investments, LLC ("DRW Investments"), DRW Commodities, LLC ("DRW Commodities") and DRW Holdings, LLC ("DRW Holdings"). DRW Holdings owns 100% of the outstanding equity of each of DRW Commodities and DRW Investments. A majority of the equity of DRW Holdings is owned, directly or indirectly, by trusts for the benefit of members of Wilson's immediate family and of which Wilson serves as trustee or investment advisor.
(2) Each of the Reporting Persons disclaims beneficial ownership of any securities held by DRW Commodities or DRW Investments, except to the extent of its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise.

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