Exhibit 23.1
Consent of Independent Registered Public Accounting Firm
We consent to the incorporation by reference in the following Registration Statements:
(1)
Registration Statement (Form S-1 No. 333-281201, 333-275870 and 333-272752);
(2)
Registration Statement (Form S-3 No. 333-267801), and
(3)
Registration Statement (Form S-8 No. 333-257446, 333-274625, 333-228794 and
333-205158);
of our report dated March 31, 2026, with respect to the consolidated financial statements of Aptose Biosciences Inc. included in this Annual Report (Form 10-K) of Aptose Biosciences Inc. for the year ended December 31, 2025.
/s/ Ernst & Young LLP
Chartered Professional Accountant
Licensed Public Accountants
Toronto, Canada
March 31, 2026