December 19, 2017
VIA EDGAR
Securities and Exchange Commission
Division of Corporation Finance
100 F. Street, N.E.
Washington, D.C. 20549
| Re: | Aptose Biosciences Inc. (the “Company”) |
Registration Statement on Form F-1 (File No. 333-221783)
Ladies and Gentlemen:
Pursuant to Rule 461 promulgated under the Securities Act of 1933, as amended (the “Securities Act”), the undersigned respectfully requests that the effective date of the above-referenced registration statement be accelerated so that the same will become effective on December 21, 2017 at 5 PM EST, or soon thereafter as is practicable.
| Very truly yours, | ||||
| Aptose Biosciences Inc. | ||||
| By: | /s/ William G. Rice | |||
| Name: Title: |
William G. Rice, Ph.D. Chairman, President and Chief Executive Officer | |||
cc: Daniel M. Miller (Dorsey & Whitney LLP)